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The Mechanisms and Functions of Transforming Growth Factors-β1 in Tendon Injury

Yujie Li, Yuanpeng Qiu, Bin Zhu, Xueli Liu, Xinyue Liu, Sheng Guo, Chenglong Wang, Dingxuan Wang, Sen Li

Tendon injury is a common injury with slow healing and is usually treated surgically and non-surgically. However, the clinical results are not always satisfactory. Growth factors play an important role in tendon healing, and people increasingly believe that biological intervention can accelerate and improve healing. In recent years, it has been discovered that therapies using bioaugmentation technology have potential benefits and injuries during the healing process of tendon. Transforming growth factors-β1 GF-β1 has been identified as a promising therapeutic target in tendon healing. A lot of evidence shows that exogenous TGF-β1 can accelerate the process of tendon repair. TGF-β1 plays an important role in tendon repair and is a very effective therapeutic agent for tendon diseases. This review summarizes the mechanism and function of TGF-β1 in the repair of tendon injuries.