आईएसएसएन: 2381-8727

सूजन, कैंसर और एकीकृत थेरेपी के अंतर्राष्ट्रीय जर्नल

खुला एक्सेस

हमारा समूह 1000 से अधिक वैज्ञानिक सोसायटी के सहयोग से हर साल संयुक्त राज्य अमेरिका, यूरोप और एशिया में 3000+ वैश्विक सम्मेलन श्रृंखला कार्यक्रम आयोजित करता है और 700+ ओपन एक्सेस जर्नल प्रकाशित करता है जिसमें 50000 से अधिक प्रतिष्ठित व्यक्तित्व, प्रतिष्ठित वैज्ञानिक संपादकीय बोर्ड के सदस्यों के रूप में शामिल होते हैं।

ओपन एक्सेस जर्नल्स को अधिक पाठक और उद्धरण मिल रहे हैं
700 जर्नल और 15,000,000 पाठक प्रत्येक जर्नल को 25,000+ पाठक मिल रहे हैं

में अनुक्रमित
  • शैक्षणिक कुंजी
  • RefSeek
  • हमदर्द विश्वविद्यालय
  • पबलोन्स
  • यूरो पब
  • आईसीएमजेई
इस पृष्ठ को साझा करें


The Immunoregulatory Role of Cytokines in Congestive Heart Failure

Chen On, Patel J, Mohamed E, Greene M,

Background: Cytokines have been shown to be associated with heart failure and to have multiple biological effects that can lead to left ventricular dysfunction, pulmonaryedema, and left ventricular remodeling. However, the effects of different cytokines, separately and in combination have not been fully determined. We aim to evaluate the levels of both pro-inflammatory and anti-inflammatory cytokines in patients with congestive heart failure (CHF), as well as in patients with coronary artery disease (CAD) and compare them to levels in normal controls (individuals without CHF or CAD) as to suggest their possible etiologic role.

Methods and results: In our study, the serum levels of IL-6, IL-10, IL-1β, IL-2 and TNF-α were measured in 19 patients with CHF, 18 patients with CAD without CHF and 8 controls, using immunoassays. There was a significant increase in the serum levels of IL-6, IL1-β, IL-10 and TNFα in the CHF group, and of IL-6, IL-1β and TNFα in the CAD group, compared with controls. Patients with CHF had significantly higher levels of anti-inflammatory cytokines IL-6 and IL-10 and lower levels of pro-inflammatory cytokines IL-2 compared when compared patients with CAD, emphasizing the different pathophysiologic mechanisms for these conditions.

Conclusion: Our studies suggest that patients with CHF had higher levels of Th2-type cytokines than patients with CAD, suggesting their role in the development of heart failure. Further studies are required to elucidate the role of cytokines in heart failure, and to understand the biological effects of cytokines and their role in the development of CHF. This may lead to development of new treatments modalities targeting their effects.