जर्नल ऑफ़ डायबिटीज़ एंड क्लिनिकल प्रैक्टिस

खुला एक्सेस

हमारा समूह 1000 से अधिक वैज्ञानिक सोसायटी के सहयोग से हर साल संयुक्त राज्य अमेरिका, यूरोप और एशिया में 3000+ वैश्विक सम्मेलन श्रृंखला कार्यक्रम आयोजित करता है और 700+ ओपन एक्सेस जर्नल प्रकाशित करता है जिसमें 50000 से अधिक प्रतिष्ठित व्यक्तित्व, प्रतिष्ठित वैज्ञानिक संपादकीय बोर्ड के सदस्यों के रूप में शामिल होते हैं।

ओपन एक्सेस जर्नल्स को अधिक पाठक और उद्धरण मिल रहे हैं
700 जर्नल और 15,000,000 पाठक प्रत्येक जर्नल को 25,000+ पाठक मिल रहे हैं

अमूर्त

Risk and Clinical Treatment of Oxidative Stress in Hypertensive Diseases Pregnancy with Gestational Diabetes Mellitus: A Prospective Cohort Study

Brona Piotr

Introduction: Oxidative stress is linked to the development of gestational diabetes mellitus (GDM). Maternal antioxidant vitamins in early pregnancy may play a role in GDM occurrence. We aimed to investigate the associations of vitamins A and E in early pregnancy with the risk of GDM and to explore whether these antioxidant vitamins can be biomarkers for the early prediction of GDM.

Methods: We carried out a prospective cohort study conducted in Beijing and enrolled pregnant women with vitamins A and E measurements at 9 weeks of gestation and having one-step GDM screened with a 75-g oral glucose tolerance test between 24 and 28 weeks of gestation.

Results: The vitamin A levels in early pregnancy were significantly higher in women with GDM than in those without GDM and positively correlated with fasting blood glucose. In multivariate models, vitamin A levels were significantly associated with GDM per SD. A significant trend of risk effect on GDM risk across quartiles of vitamin A was observed. No significant association of serum vitamin E with GDM was observed overall. However, a noted trend of protective effect on GDM risk across quartiles of vitamin E/cholesterol ratio was observed. In ROC analysis, the multivariate model consisting of vitamin A and other risk factors showed the best predictive performance.

Conclusions: Higher levels of vitamin A in early pregnancy were significantly associated with an increased risk of GDM. Vitamin A has the potential to be a biomarker indicating pathogenesis of GDM.