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अमूर्त

Regulative Effect for Granulocyte/Lymphocyte Ratio by Malted Rice through Complement Activation in Human Peripheral Blood

Hisashi Tsukada, Kazuhiro Okamoto, Nurmuhamamt Amat and Nobuo Yamaguchi

Background: A Life-related diseases had been claimed to regulated by finding some alternative medicinal process.
Objective: The purpose of this study was to find cool method to control the bias from life-related disease through granulocyte-lymphocyte ratio in human.
Method: A malted rice were prepared by Rice Yeast (MRY). This products were exhibited by safe in animal safety test. The trial was made to investigate a recovery of immune-competent cells both in granulocyte and lymphocyte ratio and CD positive lymphocyte subpopulations together with the amount of emotional hormone adrenalin and dopamine.
Result: Our results in animal model showed that MRY was the safe for the animal safety test. Four weeks after the administration, granulocyte and lymphocyte ratio was regulated as modulate and neutral. The emotional hormone adrenaline and dopamine level in serum also regulated neutral that dose dependent and reversible manner. The mechanism of this regulation had triggered by starting complement activation by absorbed MRY fragments through intestinal wall to the lymph.
Conclusion: We proposed an idea that MRY exhibited remedy effect for the regulation of immune competent cells via controlling complement component. The mechanism of activation was proved by activating alternative pathway of complement by the technic, immune-electrophoresis.