फार्मेसी और जीवन विज्ञान में अनुसंधान और विकास के अंतर्राष्ट्रीय जर्नल

अमूर्त

NOVEL APPROACHES FOR COLON TARGETED DRUG DELIVERY SYSTEM

Singh Amritpal, Sharma Ankush, Pooja, Anju

The colon is a site where both local and systemic delivery of drugs can take place. Local delivery allows topical treatment of inflammatory bowel disease. However, treatment can be made effective if the drugs can be targeted directly into the colon, thereby reducing the systemic side effects. This review, mainly compares the primary approaches for CDDS (Colon Specific Drug Delivery) namely prodrugs, pH and time dependent systems, and microbially triggered systems, which achieved limited success and had limitations as compared with newer CDDS namely pressure controlled colonic delivery capsules, CODESTM, and osmotic controlled drug delivery which are unique in terms of achieving in vivo site specificity, and feasibility of manufacturing process.