हमारा समूह 1000 से अधिक वैज्ञानिक सोसायटी के सहयोग से हर साल संयुक्त राज्य अमेरिका, यूरोप और एशिया में 3000+ वैश्विक सम्मेलन श्रृंखला कार्यक्रम आयोजित करता है और 700+ ओपन एक्सेस जर्नल प्रकाशित करता है जिसमें 50000 से अधिक प्रतिष्ठित व्यक्तित्व, प्रतिष्ठित वैज्ञानिक संपादकीय बोर्ड के सदस्यों के रूप में शामिल होते हैं।
ओपन एक्सेस जर्नल्स को अधिक पाठक और उद्धरण मिल रहे हैं
700 जर्नल और 15,000,000 पाठक प्रत्येक जर्नल को 25,000+ पाठक मिल रहे हैं
Halina Baran, Marcelin Jan Pietryja, Carina Kronsteiner and Berthold Kepplinger
The present study evaluates the action of Jerusalem Balsam with respect to the biosynthetic machinery of Kynurenic Acid (KYNA) synthesis e.g. the activity of the enzyme synthesizing KYNA, Kynurenine Aminotransferase II (KAT II) in the rat liver homogenate. Subsequently we compared the action of Jerusalem Balsam on KAT II activity in the rat liver homogenate with the action of Cerebrolysin and D-cycloserine, known to inhibit rat liver KAT II activities. We found that Jerusalem Balsam blocked dose-dependently and significantly KAT II activity in the rat liver homogenate. The effect of Jerusalem Balsam on KAT II activity comparing to action of Cerebrolysin or D-cycloserine was strong and significant and the inhibition was seen up to 5 hrs of assay incubation time. Obtained data suggest that lowering of KYNA synthesis by Jerusalem Balsam is notable biochemical effect since it might influence KYNA levels. Increased KYNA levels, respectively KYNA synthesis has been reported in stroke patient, in patient with respiration and cardiovascular problem and in neuropsychiatric disorders. The possible therapeutic mechanism and advantage of the remedy Jerusalem Balsam, i.e., mixture of plants might be due to modulation of KYNA synthesis and improvement of biochemical processes in the periphery and likely in the CNS.