हमारा समूह 1000 से अधिक वैज्ञानिक सोसायटी के सहयोग से हर साल संयुक्त राज्य अमेरिका, यूरोप और एशिया में 3000+ वैश्विक सम्मेलन श्रृंखला कार्यक्रम आयोजित करता है और 700+ ओपन एक्सेस जर्नल प्रकाशित करता है जिसमें 50000 से अधिक प्रतिष्ठित व्यक्तित्व, प्रतिष्ठित वैज्ञानिक संपादकीय बोर्ड के सदस्यों के रूप में शामिल होते हैं।
ओपन एक्सेस जर्नल्स को अधिक पाठक और उद्धरण मिल रहे हैं
700 जर्नल और 15,000,000 पाठक प्रत्येक जर्नल को 25,000+ पाठक मिल रहे हैं
Franklin Steve Azebaze Agueguia, Paul Talla, Marie Claire Okomo Assoumou, Graeme Brendon Jacobs, Cedric Happi Mbakam, Elise Guiedem, Martha Tongo Mesembe, Emilia Lyonga, George Mondinde Ikomey
Chronic Viral Hepatitis B (VHB) is characterized by a progressive destruction of hepatocytes and T-lymphocyte depletion. The mechanisms of the CD95-CD95L signaling pathway during chronic VHB and cirrhotic process remains unclear. Our objective was to evaluate the involvement of the CD95-CD95L receptor-ligands in T-lymphocyte depletion and hepatic cytolysis in patients with chronic VHB. Methods: A cross-sectional study was conducted from September to December 2018, at the Yaoundé General Hospital, Cameroon. Four milliliters of blood were collected and analyzed. The CD95, CD95L levels and CD4+, CD8+ T-cell counts were performed by ELISA and Flow cytometry, respectively. The data were analyzed using EpiInfo 7.0 and GraphPad PRISM 5.0, with the significant threshold set at p ≤ 0.05 and a 95% confidence interval. Results: Of the 130 patients, 36 (27.7%) were cirrhotic, and 94 (72.3%) were non-cirrhotic. The plasma level of CD95 and CD95L were significaly elevated in cirrhotic patients, compared with non-cirrhotic patients (p < 0.001 and p = 0.001 respectively). CD4/CD8 ratios were lower in cirrhotic patients, compared with non-cirrhotic patients (p < 0.001). There were statistically significant correlations between CD95 and CD4+, between CD95 and CD8+, between CD95 and CD4/CD8 ratio, between CD95 and fibrosis scores and between CD95L and fibrosis score. Conclusion: CD95-CD95L could be involved in T-lymphocyte depletion and hepatic cytolysis during the pathogenesis of chronic VHB, and could be used as biomarkers for immunological and hepatic monitoring in patients with chronic VHB.