हमारा समूह 1000 से अधिक वैज्ञानिक सोसायटी के सहयोग से हर साल संयुक्त राज्य अमेरिका, यूरोप और एशिया में 3000+ वैश्विक सम्मेलन श्रृंखला कार्यक्रम आयोजित करता है और 700+ ओपन एक्सेस जर्नल प्रकाशित करता है जिसमें 50000 से अधिक प्रतिष्ठित व्यक्तित्व, प्रतिष्ठित वैज्ञानिक संपादकीय बोर्ड के सदस्यों के रूप में शामिल होते हैं।
ओपन एक्सेस जर्नल्स को अधिक पाठक और उद्धरण मिल रहे हैं
700 जर्नल और 15,000,000 पाठक प्रत्येक जर्नल को 25,000+ पाठक मिल रहे हैं
Termpong Dumrisilp
Background: Obesity predisposes chronic inflammatory state that interferes to vaccine response. There are inconclusive results of correlation between obesity and hepatitis A virus (HAV) vaccine-response. There are limited data focusing on live attenuated hepatitis A vaccine. Objective: Our aim was to evaluate the effect of overweight and obesity on the response to live attenu¬ated hepatitis A vaccine in children and young adult. Methods: This was a prospective cohort study conducted at 3 schools, 1 university and 1 obesity clinic at hospital. The subjects aged 7 to 25 years were tested for baseline anti-HAV antibodies and administered 0.5 mL of live attenu¬ated hepatitis A vaccine (MEVAC-A™). Participants with seronegative defined by anti-HAV antibodies (<20 mIU/mL) were divided into three groups according to obesity defined as follows WHO classification. We evaluated immunogenicity and adverse events (AE) after 8-9 weeks from vaccination. Results: A total of 212 subjects completing the study (female: 131, median age (IQR): 13 years (11-16). Of these, 95 subjects (46%) were in overweight/obesity group. All the AE (n=106) were non-serious and most event was myalgia (34%). The seroprotection (≥20 mIU/mL antibody titer after vaccination) rates were 100 %. Post vaccination geometric mean titers of anti-HAV (IU/L) were 451.1 [95%CI: 374.76-543.0] in underweight group, 428.38 [95%CI: 399.61-459.22] in normal weight group and 467.46 [95%CI: 425.01-514.16] in overweight/obesity group. No significant differences in immunogenicity were found between 3 groups (p=0.33). Conclusion: Live attenu¬ated hepatitis A vaccine is safe and highly immunogenic because all of participants were.