क्लिनिकल फार्माकोलॉजी और बायोफार्मास्यूटिक्स

अमूर्त

Formulation of the Tazarotene Cutaneous Gel and Its Physicochemical Characteristics

Talieh Taheri, Sayed Alireza Mortazavi and Alireza Dabir Siaghi

Treatment of psoriasis is divided to three main types: moderate treatment (moisturizers, phototherapy and etc.), low treatment (changing the life style) and high treatment include systemic medications.

Tazaroten is one of the most effective and the most applicable dermal medicine in treatment of two mentioned diseases that available in form of gel, cream and foam. This agent is one component of vitamin A derivatives and it is a selective receptor of acetylene retinoid that binds to beta and gamma retinoid acid receptors.

The purpose of this study is formulation of cutaneous gel of Tazarotene 0.1% that is not available in the internal market of medication in Iran.

So, first the basics of medicine prepared after changing in several stages of amounts and proportions of primary materials and the effective agent added to better formulation after related stability tests. Then the stability of the formula evaluated in terms of clarity, pH, lack of two phases in temperature of 4°C, 25°C and 40°C as well as viscosity, and the best formulation was selected in terms of stability. Then the tests of determination of the effective material amount in wavelength 351 nm was performed by method of spectrophotometer and HPLC, release of medicine in plasmatic membrane and dermal absorption in the medium of acetate ammonium buffer with pH=6.5 and 10% acetonitrile on the final formulation.

The final formulation contained 85% effective material that was in the optimal range in terms of releasing and dermal absorption, while adhere to Higouchi kinetics model.