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अमूर्त

Evaluation of Patients Receiving Jeeva^® at an Integrative Pulmonary Care Center

Narinder Singh Parhar, Gloria St John, Ajaipal Singh Gill, Frank and Sachin A Shah

Introduction: Asthma and COPD contribute significantly to morbidity, mortality, and social-economic burden. Integrative Pulmonary Care center (IPCC) is a specialized program that has an integrative approach to respiratory care. Notably, eligible patients may receive a novel plant based therapeutic option (Jeeva®) in addition to standard of care. Jeeva® integrates several nutraceuticals known to have immune-modulatory, anti-inflammatory andantioxidantproperties. Methods: An evaluation of patient records was performed for all asthma/COPD patients enrolled in the IPCC program who had consented to consume Jeeva®. Demographic data, past medical history, and spirometry data (FEV1, FVC, FEV1/FVC, FEV1% predicted, FVC% predicted, FEV1/FVC% predicted) were collected along with a survey-based assessment of quality-of-life. The primary endpoint was the maximum change in FEV1 and FVC pre-bronchodilator after Jeeva® initiation. A paired students’ t-test was utilized to compare the maximum change post- Jeeva® from baseline. Intent-to-treat analysis was performed using the last-observation carried forward methodology. Results: A total of 26 patients were included for analyses. Median duration of Jeeva® consumption was approximately 6 months (range 1–12 months). There was a statistically significant change in FEV1 and FVC from baseline [1.64 ± 0.72 L to 1.80 ± 0.72 L; (p=0.019) and 2.26 ± 0.80L to 2.50 ± 0.74 L (p=0.004) respectively]. Quality-oflife improved statistically significantly and there was a notable decrease in medication burden. Conclusion: Patients receiving Jeeva® as part of the IPCC significantly improved pre-bronchodilator FEV1 and FVC from baseline. A small improvement in quality-of-life and medication burden was evident. Further studies looking at Jeeva® in a randomized, placebo-controlled, clinical-trial is warranted.