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Development of Green synthetic strategies involving formylated ketones

Jai N Vishwakarma

Development of Green synthetic strategies involving formylated ketones Abstract: In view of the synthetic potential and biological properties of enaminones we have developed green synthetic protocols by the reaction of formylated acetophenones with primary amines in aqueous media assisted by KHSO4. This reaction was further generalized in the presence of ultrasound thus achieving the goals within minutes instead of hours (Scheme 1). Prompted by these findings, we developed synthetic strategies for biologically potential novel pyrazolopyrimidines by reacting 2 with dinucleophiles 6 in aqueous media under ultrasound irradiation.