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An Incident Case-control Study of Nonphysiologic Neonatal Hyperbilirubinemia: Evaluation of Pre and Perinatal Risk Factors

Marta Szmuda, Marta Zawadzka, Seweryna Konieczna and Maria Mazurkiewicz-Bełdzińska

Introduction: Neonatal jaundice is a well-known phenomenon which can be potential cause of permanent brain damage.

Methods: There were 621 infants included in the retrospective case-control study: 590 were a control group (physiological jaundice), 31 were study group (nonphysiologic hyperbilirubinemia.

Results: There were significantly more cases of usage pregnancy sustaining drugs and forceps delivery in neonates who developed hyperbilirubinemia. Mean values of Apgar score, weight, height and head circumference statistically correlated with hyperbilirubinemia occurrence.

Conclusions: The study indicates that pregnancy sustaining drugs and using forceps during delivery increase risk of hyperbilirubinemia incidents. The study underlines that severe hyperbilirubinemia is often connected with prematurity and unfavorable general health state.